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1.
J Int Med Res ; 51(12): 3000605231222244, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38140948

RESUMO

Herein, we describe a case of acute rhabdomyolysis in a man in his early 50s undergoing haemodialysis and receiving the antiviral drug, telbivudine, for chronic hepatitis B virus (HBV) infection. Following diagnosis by electromyography (EMG), magnetic resonance image (MRI) scans and laboratory data (i.e., elevated serum creatinine kinase (CK) and myoglobin) telbivudine was discontinued and the patient was treated with methylprednisolone. While his CK and myoglobin levels decreased rapidly, his muscle weakness and pain improved slowly. Learning points include: patients undergoing haemodialysis and concomitantly receiving antiviral treatment for HBV, should have their serum levels of CK and myoglobin monitored regularly; treatment with corticosteroids maybe required; relief from rhabdomyolysis-induced muscle weakness and pain may be slow due to nerve fibre damage.


Assuntos
Hepatite B Crônica , Rabdomiólise , Masculino , Humanos , Telbivudina/efeitos adversos , Hepatite B Crônica/complicações , Hepatite B Crônica/tratamento farmacológico , Antivirais/efeitos adversos , Mioglobina/efeitos adversos , Timidina/efeitos adversos , Rabdomiólise/induzido quimicamente , Rabdomiólise/tratamento farmacológico , Diálise Renal , Dor/tratamento farmacológico , Debilidade Muscular
2.
Materials (Basel) ; 16(9)2023 May 08.
Artigo em Inglês | MEDLINE | ID: mdl-37176481

RESUMO

Extruded Al-Mg-Si profiles applied in the automotive industry are required to achieve an appropriate combination of strength and bendability. In order to investigate the effect of Mg/Si ratio on the bendability and anisotropic bending behavior, AA6005 and AA6061C were extruded to 2 mm thick plates. More Goss texture and anisotropic particle clusters exist in AA6005 alloys with a low Mg/Si ratio, which leads to a high tendency of surface roughing and cracking and to strong anisotropy in their bendability. However, more low-angle grain boundaries, cubic texture and comparatively random distribution of particles exists in AA6061C alloys with a high Mg/Si ratio, which blunts the surface roughing and crack process. The surface undulation is the outcome of the strain-intense localization of several layers of grains in the vicinity of the outer elongated surface. The strain localization and surface undulation lead to shear band initiation near the valleys. Several cooperating micro-mechanisms in AA6005, including grain clusters with Goss and Cubic orientation, heterogeneously nucleated particles and grain boundary spatial arrangements, lead to the grain boundary decohesion along a shear direction. AA6005 shows for predominately intergranular fractures in nature, with some areas exhibiting grain boundary decohesion during bending in the TD. However, AA6061C shows a predominately transgranular in nature, with some areas exhibiting intergranular fracture, which is affected by shear band development.

3.
Materials (Basel) ; 16(7)2023 Mar 31.
Artigo em Inglês | MEDLINE | ID: mdl-37049094

RESUMO

An innovative brush plating process for preparing coatings on the inner wall of metal pipes is proposed, which aims to solve the limitations of current electroplating technology and improve the performance of the inner walls of metal pipes. While optimizing the process, the effect of working voltage on the microhardness, thickness, surface morphology, corrosion resistance, and elastoplasticity of the Ni coating on the inner wall of the tube was studied under the new process. The results indicate this technique can produce high-quality coatings on the inner wall of pipes in a simple and efficient manner. As the working voltage increases, the surface quality and comprehensive performance of the coating show an increasing trend followed by a decreasing trend. At 12 V, the coating exhibits the highest surface density and uniformity, the lowest surface roughness, the best corrosion resistance, and the maximum microhardness of 575.8 HV, with a corrosion current density of 1.040 × 10-5 A·cm-2, a corrosion rate of 0.122 mm·a-1, the maximum elastic recovery ratio he/hmax of 0.36, and the best deformation resistance. This study demonstrated the effectiveness of this method in improving the durability and functionality of metal pipes and its potential for various industrial applications.

4.
BMC Nephrol ; 23(1): 256, 2022 07 18.
Artigo em Inglês | MEDLINE | ID: mdl-35850695

RESUMO

BACKGROUND: The inflammatory bowel disease, containing Crohn's disease and ulcerative colitis, was rare in the population, especially in the complication of kidney disease. A few studies had found proteinuria played a potential indicator of inflammatory bowel disease occurrence and activity. This study aimed to better define the histopathologic spectrum and study the outcome of renal disease in Crohn's disease. METHODS: A retrospective study of 3557 Crohn's disease from January 1st, 2016 to July 1st, 2021 in the Sixth Affiliated Hospital of Sun Yat-sen University identified 20 (0.56% [20/3557]) patients who underwent kidney biopsy. All biopsy specimens were examined by standard procedures containing light microscopy, immunofluorescence, and electron microscopy. RESULTS: Twenty cases were shown in this review study. Subnephrotic proteinuria (30% [6 of 20]), persistent hematuria and proteinuria (25% [5 of 20]), and isolated hematuria with acanthocytes (25% [5 of 20]) were the main indications for kidney biopsy. The most common diagnosis was IgA nephropathy (70% [14/20]), followed by minimal change disease (10% [2/20]), acute interstitial nephritis (5% [1/20]), granulomatous interstitial nephritis (5% [1/20]), non-IgA mesangial proliferative nephritis (5% [1/20]) and thin basement membrane nephropathy (5% [1/20]). The Lee classification of IgA nephropathy was mostly II or III level. Glomerular mesangial hyperplasia was the most common pathologic manifestation according to the MEST-C Sore. After twelve-month treatment, the majority of patients turned to complete remission of renal disease by measuring proteinuria, while 3 patients still stayed in the relapse stage and 6 patients turned to partial remission by measuring hematuria. CONCLUSIONS: IgA nephropathy is the most common kidney biopsy diagnosis in Crohn's disease. Renal damage in Crohn's disease mainly involves the glomerulus, especially the mesangial matrix. After the treatment, proteinuria might be in remission, but hematuria remains.


Assuntos
Doença de Crohn , Glomerulonefrite por IGA , Nefrite Intersticial , Biópsia/efeitos adversos , Doença Crônica , Doença de Crohn/complicações , Doença de Crohn/diagnóstico , Glomerulonefrite por IGA/complicações , Glomerulonefrite por IGA/patologia , Hematúria/patologia , Humanos , Rim/patologia , Nefrite Intersticial/patologia , Proteinúria/epidemiologia , Estudos Retrospectivos
5.
Nefrología (Madrid) ; 41(5): 548-555, sep.-oct. 2021. tab, graf
Artigo em Inglês | IBECS | ID: ibc-227934

RESUMO

Background: Ubiquitin-52 amino acid fusion protein (UbA52) is an important factor in the pathogenesis of diabetic kidney disease (DKD) and has been suggested a potential marker in the disease. However, whether upregulation of UbA52 marks early kidney injury in T2DM mellitus (T2DM) patients remains unclear. In this study, we examine the diagnostic value of UbA52 as a biomarker in predicting early diabetic kidney disease (DKD) in T2DM patients. Methods: We used two-step ELISA to test UbA52 level in urine of 3 defined patient groups. Samples from T2DM patients without albuminuria or diabetic retinopathy (DM-WNP; n=30), T2DM patients with albuminuria and diabetic retinopathy, excluding other renal diseases clinically (DM-NP; n=30) and healthy controls (n=30) were analyzed. Spearman's correlation analysis and multiple linear regression model were used to analyze the correlation of urinary UbA52 level with laboratory results regarding kidney function. Receiver operating characteristic curve (ROC) was used to evaluate the diagnostic value of UbA52 in predicting T2DM and early DKD. Results: Urinary UbA52 level in DM-NP group was 1.75 times and 2.71 times higher than in DN-WNP (p=0.004) and normal control group (p<0.001), respectively. The level of urinary UbA52 correlated significantly with serum creatinine (r=0.468, p<0.001), GFR (r=−0.300, p=0.004) and proteinuria (r=0.484, p<0.001). Multiple linear regression analysis showed that proteinuria level was independently associated with urinary UbA52 level (β=0.833, p<0.001). The area under the ROC of urinary UbA52 in diagnosing T2DM and DKD was 0.751 and 0.755, respectively. (AU)


Antecedentes: La proteína de fusión de aminoácidos ubiquitina-52 (UbA52) es un factor importante en la patogénesis de la enfermedad renal diabética (ERD), y se ha sugerido como marcador potencial en la enfermedad. Sin embargo, aún no está claro si la regulación al alza de UbA52 indica una lesión renal temprana en pacientes con diabetes mellitus de tipo 2 (DMT2). En este estudio, analizamos el valor diagnóstico de UbA52 como biomarcador para predecir la ERD temprana en pacientes con DMT2. Métodos: Utilizamos un ELISA de 2 pasos para analizar el nivel de UbA52 en la orina de 3 grupos de pacientes definidos. Se analizaron muestras de pacientes con DMT2 sin albuminuria o retinopatía diabética (DM-WNP; n=30), pacientes con DMT2 y con albuminuria y retinopatía diabética, excluyendo clínicamente otras enfermedades renales (DM-NP; n=30) y controles sanos (n=30). Se utilizó el análisis de correlación de Spearman y el modelo de regresión lineal múltiple para analizar la correlación del nivel de UbA52 en orina con los resultados de laboratorio relativos a la función renal. Se utilizó la curva de características operativas del receptor (ROC) para evaluar el valor diagnóstico de UbA52 en la predicción de la DMT2 y de la ERD temprana. Resultados: El nivel de UbA52 en orina en el grupo DM-NP fue 1,75 y 2,71 veces mayor que en el grupo DN-WNP (p=0,004), y en el grupo de control normal (p<0,001), respectivamente. El nivel de UbA52 en orina se correlacionó significativamente con la creatinina sérica (r=0,468; p<0,001), la TFG (r=−0,300; p=0,004) y la proteinuria (r=0,484; p<0,001). El análisis de regresión lineal múltiple mostró que el nivel de proteinuria se asociaba de forma independiente al nivel de UbA52 en orina (β=0,833; p<0,001). El área bajo las ROC de UbA52 en orina en el diagnóstico de la DMT2 y de la ERD fue de 0,751 y 0,755, respectivamente. (AU)


Assuntos
Humanos , Ubiquitinas , Nefropatias/diagnóstico , Diabetes Mellitus Tipo 2 , Ensaio de Imunoadsorção Enzimática , Nefropatias Diabéticas , Albuminúria , Proteinúria
6.
Nefrologia (Engl Ed) ; 41(5): 548-555, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-36165137

RESUMO

BACKGROUND: Ubiquitin-52 amino acid fusion protein (UbA52) is an important factor in the pathogenesis of diabetic kidney disease (DKD) and has been suggested a potential marker in the disease. However, whether upregulation of UbA52 marks early kidney injury in T2DM mellitus (T2DM) patients remains unclear. In this study, we examine the diagnostic value of UbA52 as a biomarker in predicting early diabetic kidney disease (DKD) in T2DM patients. METHODS: We used two-step ELISA to test UbA52 level in urine of 3 defined patient groups. Samples from T2DM patients without albuminuria or diabetic retinopathy (DM-WNP; n=30), T2DM patients with albuminuria and diabetic retinopathy, excluding other renal diseases clinically (DM-NP; n=30) and healthy controls (n=30) were analyzed. Spearman's correlation analysis and multiple linear regression model were used to analyze the correlation of urinary UbA52 level with laboratory results regarding kidney function. Receiver operating characteristic curve (ROC) was used to evaluate the diagnostic value of UbA52 in predicting T2DM and early DKD. RESULTS: Urinary UbA52 level in DM-NP group was 1.75 times and 2.71 times higher than in DN-WNP (p=0.004) and normal control group (p<0.001), respectively. The level of urinary UbA52 correlated significantly with serum creatinine (r=0.468, p<0.001), GFR (r=-0.300, p=0.004) and proteinuria (r=0.484, p<0.001). Multiple linear regression analysis showed that proteinuria level was independently associated with urinary UbA52 level (ß=0.833, p<0.001). The area under the ROC of urinary UbA52 in diagnosing T2DM and DKD was 0.751 and 0.755, respectively. CONCLUSION: The level of urinary UbA52 increased significantly in T2DM patients with DKD. The level of proteinuria is independently associated with urinary UbA52 level. Urinary UbA52 could serve as an early marker in the diagnosis of DKD. CLINICALTRIALS: gov Identifier: NCT02204280.


Assuntos
Diabetes Mellitus Tipo 2 , Nefropatias Diabéticas , Retinopatia Diabética , Albuminúria/complicações , Aminoácidos , Biomarcadores , Creatinina/urina , Diabetes Mellitus Tipo 2/complicações , Nefropatias Diabéticas/diagnóstico , Nefropatias Diabéticas/etiologia , Humanos , Ubiquitinas
8.
BMC Nephrol ; 21(1): 337, 2020 08 12.
Artigo em Inglês | MEDLINE | ID: mdl-32787784

RESUMO

BACKGROUND: Percutaneous renal biopsy (PRB) is the primary biopsy technique and it was used by 16G needles or 18G needles in China, but there is controversy about the effect and safety of the two different diameters. The study aims to compare the adequacy, complication rate and pathological classification when using 18G vs. 16G needles to perform renal biopsy with ultrasound-guidedance on native kidneys in Chinese individuals. METHODS: We retrospectively analyzed the number of glomeruli, adequate sample rates, complication rates and pathological classification in 270 patients with the use of 18G or 16G needles from January 2011 to May 2017 and verified whether the needle gauge affected the disease diagnosis. RESULTS: A total of 270 kidney biopsies were performed. Among them,72 were performed with 18G needles, and 198 were performed with 16G needles. There was no difference in the number of glomeruli under light microscope using 18G relative to 16G needles (24 ± 11 vs. 25 ± 11, p = 0.265), whereas more glomeruli were found in the 16G group than in the 16G group using immunofluorescence microscopy (3 ± 2 vs. 5 ± 3, p < 0.05). There was no significant difference in the adequate sample rates between the 18G group and the 16G group (90.28% vs. 93.94%, p = 0.298). Minor complications including the incidence of lumbar or abdominal pain (4.17% vs. 7.07%, p = 0.57), gross hematuria (4.17% vs. 3.54%, p = 0.729), and perinephric hematoma without symptoms (4.17% vs. 1.52%, p = 0.195), were not significantly different between the 18G and 16G groups. In the 16G group, 2 cases of serious complications occurred: severe gross hematuria requiring blood transfusion and retroperitoneal hematoma requiring surgery. No serious complications were observed in the 18G group, although there was no significant difference in serious complications rates between the 18G and 16G groups (0% vs. 1.02%, p = 1). CONCLUSION: There was no significant difference in the number of glomeruli, adequate sample rates, or complication rates when using 18G or 16G needles to perform renal biopsy, and the use of an 18G needle with a smaller diameter did not affect the pathological diagnosis or classification of IgA nephropathy and lupus nephritis.


Assuntos
Dor Abdominal , Anemia , Biópsia por Agulha , Hematoma , Hematúria , Rim , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem , Dor Abdominal/epidemiologia , Anemia/epidemiologia , Anemia/etiologia , Anemia/terapia , Transfusão de Sangue/estatística & dados numéricos , China/epidemiologia , Embolização Terapêutica/estatística & dados numéricos , Hematoma/epidemiologia , Hematoma/etiologia , Hematúria/epidemiologia , Hematúria/terapia , Rim/patologia , Glomérulos Renais/patologia , Agulhas , Espaço Retroperitoneal , Biópsia por Agulha/efeitos adversos , Biópsia por Agulha/instrumentação
9.
Diagn Pathol ; 14(1): 41, 2019 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-31092271

RESUMO

BACKGROUND: Lipoprotein glomerulopathy (LPG) is a rare kidney disease with a poor prognosis that is related to mutation of the apoE gene. More than 10 variants of apoE associated with LPG have currently been identified. CASE PRESENTATION: A male and his mother presented with proteinuria during a health examination. They went to hospital for further examination. Renal biopsy was performed, and the diagnosis was lipoprotein glomerulopathy (LPG), which is a rare, inherited renal disease. Medical histories were collected from the 2 LPG patients and their family members. The patients and family members underwent a routine urine test, and their renal function, blood lipids, and lipoprotein levels were examined. Genomic DNA was extracted from the peripheral blood of 7 family members, and exon 2, exon 3 and exon 4 of apoE were amplified by polymerase chain reaction (PCR). The purified PCR products were sequenced. Sequence analysis identified a 15 bp deletion (GCGCAAGCTGCGTAA) in exon 4 of the apoE gene that results in a novel 5 amino acid deletion in apoE (143 K-147R → 0). No mutations were found in exon 2 and exon 3 of the apoE gene. CONCLUSIONS: This family study suggests that a novel ApoE mutation (143 K-147R → 0) may be etiologically related to LPG, and other genetic or environmental factors may be associated with the occurrence of LPG.


Assuntos
Apolipoproteínas E/genética , Nefropatias/genética , Aminoácidos/genética , Povo Asiático , Éxons/genética , Feminino , Humanos , Rim/patologia , Nefropatias/diagnóstico , Nefropatias/patologia , Glomérulos Renais/patologia , Lipídeos , Masculino , Mutação , Linhagem , Deleção de Sequência
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